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Superoxide production by rabbit pulmonary alveolar macrophages.
Authors:D B Lowrie  V R Aber
Affiliation:MRC Unit for Laboratory studies of tuberculosis, Royal Postgraduate Medical School, Du Cane Road, London W12 OHS, UK
Abstract:Nitroblue tetrazolium (NBT) reduction by reduction by alveolar macrophages from normal and BCG-granulomatous rabbit lungs was inhibited by superoxide dismutase (SOD). Superoxide (.O2?) might therefore be involved, either direclty or indirectly, in the bactericidal activities of such cells. Cells from BCG-granulomatous rabbits did not, however, reduce significantly more NBT per cell than cells from normal rabbits.
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