Superoxide production by rabbit pulmonary alveolar macrophages. |
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| Authors: | D B Lowrie V R Aber |
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| Affiliation: | MRC Unit for Laboratory studies of tuberculosis, Royal Postgraduate Medical School, Du Cane Road, London W12 OHS, UK |
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| Abstract: | Nitroblue tetrazolium (NBT) reduction by reduction by alveolar macrophages from normal and BCG-granulomatous rabbit lungs was inhibited by superoxide dismutase (SOD). Superoxide (.O2?) might therefore be involved, either direclty or indirectly, in the bactericidal activities of such cells. Cells from BCG-granulomatous rabbits did not, however, reduce significantly more NBT per cell than cells from normal rabbits. |
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