反复电针对慢性痛的累加治疗作用及其机制研究

本研究从基础和临床两方面观察了反复电针对慢性痛的累加治疗作用，并结合疼痛患者及慢性痛动物模型中几种神经肽的放射免疫测定及相应受体拮抗剂的药理学研究结果，探讨了产生累加效应的可能机制。结果表明，在临床脊髓损伤性痉挛患者，１００Ｈｚ穴位体表电刺激有效地缓解痉挛并有累加效应；在临床慢性痛患者，２／１５Ｈｚ变频ＴＥＮＳ刺激有效地治疗疼痛并具有累加效应。在关节炎模型大鼠，电针刺激能产生明显的镇痛并具有累加效

A Study on the Cumulative Effect of Repeated Electroacupuncture on Chronic Pain

Clinical and animal studies were performed to evaluate the effect of repeated transcutaneous electric nerve stimulation(TENS)applied on acupoints of pain patients and the effect of repeated electroacupuncture(EA)at acupoints of the rat on experimental arthritic pain models.Attempts were also made to evaluate whether substance P(SP),cholecystokinin octopeptide(CCK-8),and met5-enkephalin(MEK)are involved in the mechanism of the cumulative effect of repeated EA on experimental arthritis using neuropharmacological(receptor antagonists)and neurochemical(radioimmunoassay,RIA)approach. The main results show that repeated TENS of 100Hz relieves spinal spasticity in a cumulative manner,while TENS of 2/15Hz is effective in relieving chronic pain.In animal chronic pain models,repeated EA suppressed the hyperalgesia in arthritic rats in a cumulative manner.Further studies revealed that in pain patients there was a plastic change in the release and metabolic rate of spinal opioid peptides.In arthritic rats there was also a change in the releasing rate of spinal SP,CCK-8,and MEK as compared to control rats,an effect modulated by repeated EA.These plastic changes occured under chronic pain condition and their modulation by repeated acupoint stimulation may explain the mechanisms of the cumulative effect of acupuncture on chronic pain.