| 胰岛素蛋白质工程：[B9Glu]人胰岛素 |
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| 引用本文： | 刘滨,梁镇和.胰岛素蛋白质工程：[B9Glu]人胰岛素[J].生物化学与生物物理学报,1996,28(3):245-249. |
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| 作者姓名： | 刘滨 梁镇和 |
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| 作者单位： | 中国科学院上海生物化学研究所，分子生物学国家重点实验室 |
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| 摘 要： | 用基因定位突变方法将胰岛素Ｂ链第９位的Ｓｅｒ改为Ｇｌｕ。获得速效胰岛素─—［Ｂ９Ｇｌｕ］人胰岛素．它的受体结合能力和体内生物活力分别为猪胰岛素的２１％和４０％。
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| 关 键 词： | 胰岛素 人胰岛素 蛋白质工程 |
Protein Engineering of Insulin:[B9Glutamic Acid] Human Insulin |
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| LIU Bin,LIANG Zhen-He,TANG Yue-Hua,ZHANG Xin-Tang,ZHU Shang-Quan,and FENG You-Min.Protein Engineering of Insulin:[B9Glutamic Acid] Human Insulin[J].Acta Biochimica et Biophysica Sinica,1996,28(3):245-249. |
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| Authors: | LIU Bin LIANG Zhen-He TANG Yue-Hua ZHANG Xin-Tang ZHU Shang-Quan and FENG You-Min |
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| Abstract: | B9Ser of insulin B chain was substituted by Gln using site-directed mutagenesis to obtain a fast-acting insulin-B9Glu] human insulin. The receptor binding capacity and in vivo biological activity of B9Glu] human insulin are 21% and 40% as those of porcine insulin respectiyely. |
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| Keywords: | B9Glu] human insulin Protein engineering Fastacting insulin |
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