Escherichia coli bind to urinary bladder epithelium through nonspecific sialic acid mediated adherence |
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Authors: | Sakarya Serhan Ertem Gunay Tuncer Oncu Serkan Kocak Izzet Erol Nural Oncu Selcan |
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Institution: | Division of Infectious Diseases and Clinical Microbiology, Department of Medicine, School of Medicine, Adnan Menderes University, 09100 Aydin, Turkey. serhansakarya@yahoo.com |
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Abstract: | The first step in the bacterial colonization and infection of uropathogenic Escherichia coli is adherence to uroepithelium. Over 80% of all urinary tract infections are caused by E. coli. Uropathogenic E. coli express several adherence factors including type 1 and P fimbriae, which mediate attachment to the uroepithelium through specific binding to different glycoconjugate receptors. We showed that P and type 1 fimbriae are not the sole adhesins on uropathogenic E. coli and sialic acid also mediates nonspecific bacterial adherence of uropathogenic E. coli and urinary bladder epithelium. |
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Keywords: | Bacterial adherence Sialic acid Neuraminidase Urinary bladder epithelium |
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