1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase |
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| Authors: | Luciana E. S. F. Machado Rebecca Page Wolfgang Peti |
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| Affiliation: | 1.Department of Molecular Pharmacology, Physiology and Biotechnology,Brown University,Providence,USA;2.Department of Molecular Biology, Cell Biology and Biochemistry,Brown University,Providence,USA;3.Department of Chemistry and Biochemistry,University of Arizona,Tucson,USA |
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| Abstract: | ![]()
The sequence-specific backbone assignment of hematopoietic protein tyrosine phosphatase (HePTP; PTPN7) in presence of vanadate has been determined, based on triple-resonance experiments using uniformly [13C,15N]-labeled protein. These assignments facilitate further studies of HePTP in the presence of inhibitors to target leukemia and provide further insights into the function of protein tyrosine phosphatases. |
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