|
|||||
|
|
Integrative expression system for delivery of antibody fragments by lactobacilli |
|
| Authors: | Martín M Cruz Pant Neha Ladero Victor Günaydin Gökçe Andersen Kasper Krogh Alvarez Beatriz Martínez Noelia Alvarez Miguel A Hammarström Lennart Marcotte Harold |
| Institution: | Instituto de Productos Lácteos de Asturias (IPLA, CSIC), 3300 Villaviciosa, Asturias, Spain,1 Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden2 |
| Abstract: | A series of expression cassettes which mediate secretion or surface display of antibody fragments was stably integrated in the chromosome of Lactobacillus paracasei. L. paracasei producing surface-anchored variable domain of llama heavy chain (VHH) (ARP1) directed against rotavirus showed efficient binding to rotavirus and protection in the mouse model of rotavirus infection. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |