Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3

Authors:	Argimón Silvia Fanning Saranna Blankenship Jill R Mitchell Aaron P

Affiliation:	¹Department of Microbiology and Institute of Cancer Research, Columbia University, New York, New York 10032;²Department of Microbiology, University College Cork, Cork, Ireland;³Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213

Abstract:	Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.

Keywords:
本文献已被 PubMed 等数据库收录！