The coding function of nucleotide sequences can be discerned by statistical analysis |
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| Authors: | M J Shulman C M Steinberg N Westmoreland |
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| Affiliation: | 1. Basel Institute for Immunology, Grenzacherstrasse 487, Postfach, 4005 Basel 5, Switzerland;2. Laboratory of Molecular Biology, National Cancer Institute NIH, Bethesda, Md., U.S.A. |
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| Abstract: | ![]()
The nucleotide sequences of the RNA phage MS2 and the DNA phage φX were subjected to statistical analysis. This analysis alone indicates (a) that the genetic code is a non-overlapping triplet code and (b) what the correct reading frame is. The application of these methods to identify structure in sequences of unknown function is discussed. |
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