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Cholestryl-phosphoryl-choline in lipid bilayers.
Authors:M Lyte  M Shinitzky
Affiliation:Department of Membrane Research, The Weizmann Institute of Science, Rehovot Israel
Abstract:Cholesteryl-phosphoryl-choline (CPC), a hybrid between cholesterol and lecithin, is incorporated into sonicated liposomes and erythrocyte membranes similarly to cholesterol. The effect of CPC on lipid microviscosity and degree of order is smaller, but not significantly than that of cholesterol. It is proposed that CPC may be employed as an efficient modulator of lipid dynamics.
Keywords:ANS  1,8-analinonaphthalene sulphonate  cmc  critical micelle concentration  CPC  cholesteryl-phosphoryl-choline  C/PL  cholesterol/phospholipid mol ratio  DPH  1,6-diphenyl hexatriene  HBS  HEPES-buffered saline  PC  phosphatidyl choline  PS  phosphatidyl serine
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