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HDACs and the senescent phenotype of WI-38 cells |
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| Authors: | Robert?F?Place,Emily?J?Noonan,Charles?Giardina mailto:giardina@uconnvm.uconn.edu" title=" giardina@uconnvm.uconn.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA |
| Abstract: | BackgroundNormal cells possess a limited proliferative life span after which they enter a state of irreversible growth arrest. This process, known as replicative senescence, is accompanied by changes in gene expression that give rise to a variety of senescence-associated phenotypes. It has been suggested that these gene expression changes result in part from alterations in the histone acetylation machinery. Here we examine the influence of HDAC inhibitors on the expression of senescent markers in pre- and post-senescent WI-38 cells. |
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