The gene for catalase is assigned between the antigen loci MIC4 and MIC11 |
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| Authors: | P Couillin M Azoulay P Metezeau M C Grisard C Junien |
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| Institution: | Génétique et Pathologie foetale, INSERM U. 73, Chateau de Longchamp, Paris, France. |
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| Abstract: | Genetic analysis of the cells of a WAGR patient (W, predisposition to Wilms tumor; A, aniridia; G, genitourinary abnormalities; R, mental retardation), bearing a partial deletion of band 11p13, was performed with biochemical and antigenic 11p markers by using gene dosage, somatic hybridization, molecular hybridization, and indirect immunofluorescence techniques. These studies allowed the regional assignment of the gene for catalase, which is linked to the Wilms tumor locus, between MIC4 and MIC11, two loci encoding for membrane antigens previously mapped to band 11p13. |
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