Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii |
| |
Institution: | 1. Acute Critical Illness Center,Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai 201508, China;2. Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China;3. Department of Pharmacy, Shanghai First Maternity and Infant Hospital, Tongji University School of medicine, Shanghai 201204, China |
| |
Abstract: | A search for bioactive natural products as anticancer lead compounds has led to the isolation of five new clerodane diterpenoids (1–5) from the twigs of Casearia kurzii. Their structures were elucidated by extensive analysis of their NMR, IR, and HRESIMS data, and the absolute configurations were determined by experimental and calculated electronic circular dichroism (ECD) data analysis. The isolates were biologically evaluated and showed cytotoxic activities toward human lung cancer cells (A549), human cervical cancer cells (HeLa), and human hepatocellular carcinoma cells (HepG2). The most active compound (5) with an IC50 value of 5.3 μM against HeLa cells, was found to induce apoptosis and arrest the HeLa cell cycle at G0/G1 stage to exert cytotoxic effects. |
| |
Keywords: | Clerodane diterpenoids Cytotoxic activities Apoptosis Cell cycle |
本文献已被 ScienceDirect 等数据库收录! |
|