Potential chemical transformation of phosphinic acid derivatives and their applications in the synthesis of drugs |
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Institution: | 1. Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt;2. Applied Organic Chemistry Department Chemical Industries Research Institute, National Research Centre, Dokki, Giza 12622, Egypt;3. Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt;4. School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK;5. Agricultural Microbiology Department, National Research Centre, Dokki, Giza 12622, Egypt |
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Abstract: | The chemical transformation of phosphinic acid is a well-considered mature area of research on account of the historical significant reactions such as Kabachnik–Fields, Mannich, Arbuzov, Michaelis–Becker, etc. Considerable advances have been made over last years especially in metal-catalyzed, free-radical processes and asymmetric synthesis using catalytic enantioselective. As a result, the aim of this synopsis is to make the reader familiar with advances in the approaches of phosphinic acids toward the synthesis of highly functionalized and valuable buildings blocks. Another purpose of this survey is to provide the current status of the applications of phosphinic acids in the synthesis of drugs. |
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