The Presence of Phospholipase D In Rat Central Nervous System Axolemma |
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| Authors: | George H DeVries Robert J Chalifour Julian N Kanfer |
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| Institution: | Department of Biochemistry, Medical College of Virginia, Richmond, Virginia, U.S.A. and;Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada |
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| Abstract: | An axolemma-enriched fraction prepared from a purified myelinated axon fraction isolated from rat CNS was found to contain phospholipase D at a specific activity similar to that of a microsomal fraction isolated from whole brain. There was a concomitant threefold enrichment in the specific activity of phospholipase D and acetylcholinesterase in the axolemma-enriched fraction compared with the specific activities of these enzymes in the starting white matter whole homogenate. This axonal phospholipase D may be involved in remodeling of phospholipid, which in turn may affect axonal functions such as ion translocation. |
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| Keywords: | Phospholipase D CNS Axolemma Microsomes |
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