大黄联合抗生素治疗脑出血合并肺部感染的临床疗效观察

目的：观察大黄联合抗生素治疗脑出血后肺部感染的临床疗效。方法：96例急性高血压脑出血血肿清除术后并发肺部感染患者随机分为治疗组（56例）和对照组（40例）。对照组应用抗生素治疗，治疗组在抗生素治疗的基础上加用大黄6g，以温开水100mL调匀后经胃管鼻饲，每日2次，共治疗7天。治疗结束后比较和评价两组的治疗效果效果。结果：治疗组患者肺哆音消失的时间、炎症消散的时间和平均治愈天数分别为3．52±1．81、10．32±3．25、10．73±3．26天，较对照组（分别为10．86±3．43、13．51±2．66、14．73±3．11）均显著缩短，差异有显著统计学意义（P〈0．01）。治疗组和对照组治疗总有效率分别为94．64％和85％，差异有统计学意义（P〈0．05）。两组不良反应的发生率比较无统计学差异（P〉0．05）。结论：大黄联合抗生素治疗脑出血术后合并肺部感染，可缩短治疗时间，提高疗效，且无严重不良反应。

Clinical Observation on the Efficacy of Rhubarb plus Antibiotics in the Treatment of Cerebral Hemorrhage with Lung Infection＊

Objective： To analyze the clinical efficacy of rhubarb plus antibiotics in the treatment of cerebral hemorrhage with lung infection. Methods： 96 patients with pulmonary infection who had accepted cerebral hematoma dissection were randomly divided into two groups. 56 patients who were enrolled in the treatment group were treated with rhubarb （6 g in 100 mL warm water, nasal feeding via detaining gastric tube, bid, in total 7 days） and antibiotics, while 40 patients who were enrolled in the control group were only treated with antibiotics. Results： The time of disappearance of rales, remission of inflammation and course of treatment were respectively 3.52±1.81, 10.32±3.25, 10.73±3.26 days in the treatment group, which were all significantly shorter than those in the control group （10.86±3.43, 13.51± 2.66, 14.73±3.11 days （P〈0,05）. The total effective rate of treatment group and control group were respectively 94.64% and 85%（P〈0.05）. No significant difference of the incidence rate of adverse reactions was observed between two groups（P〉0.05）. Conclusion： Rhubarb plus antibiotics Can short the course of treatment of patients with pulmonary infection who had accepted cerebral hematoma dissection and do not produce adverse reactions.