Effects of partial destruction of the suprachiasmatic nuclei on two circadian parameters: wheel-running activity and short-day induced testicular regression |
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Authors: | Gary E Pickard Fred W Turek |
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Institution: | (1) Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, 10032 New York, New York, USA;(2) Department of Neurobiology and Physiology, Northwestern University, 60201 Evanston, Illinois, USA;(3) Present address: Institute of Neuroscience, University of Oregon, 97403 Eugene, OR, USA |
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Abstract: | Summary Many circadian rhythms in mammals are regulated by the suprachiasmatic nuclei located in the anterior hypothalamus. The suprachiasmatic nuclei are a heterogeneous population of neurons loosely segregated into regions. In an effort to determine if a regional specificity of control of different circadian rhythms exists within the SCN, the effect of small electrolytic lesions of the suprachiasmatic nuclei was examined on two parameters which are known to depend on the circadian system for their normal expression: wheel-running activity and short-day induced testicular regression. While some SCN lesions altered both the circadian rhythm of locomotor activity and the normal temporal pattern of gonadal regression on short-days, other partial lesions of the suprachiasmatic nuclei were found to effect one parameter without effecting the other. Detailed histological analysis of the neural damage sustained by the suprachiasmatic nuclei did not indicate an obvious regional specificity of function within the nuclei. However, the results do suggest that functionally specific neural pathways emerging from the suprachiasmatic nuclei carry circadian information to independent neural circuits responsible for locomotor activity and neuroendocrine-gonadal function.Abbreviations
SCN
suprachiasmatic nucleus
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SCG
superior cervical ganglion
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NAT
N-acetyltransferase
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LD
light/dark cycle
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DD
constant darkness
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circadian period
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phase angle of entrainment
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HRP
horseradish peroxidase
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SEM
standard error of the mean
- vPVN
hypothalamic paraventricular nucleus
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DMH
hypothalamic dorsomedial nucleus
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PVT
thalamic paraventricular nucleus
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IMLN
intermediolateral nucleus |
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