Adriamycin inhibits the formation of non-bilayer lipid structures in cardiolipin-containing model membranes |
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Authors: | E Goormaghtigh M Vandenbranden JM Ruysschaert B de Kruijff |
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Institution: | 1. Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, Campus Plaine CP. 206/2, 1050 Bruxelles Belgium;2. Institute of Molecular Biology, State University of Utrecht, Padualaan 8, 3508 TB Utrecht The Netherlands |
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Abstract: | The effect of adriamycin on cardiolipin-containing model membrane systems have been studied by 31P-NMR, freeze-fracture electron microscopy and binding experiments. Adriamycin effectively inhibits the formation of non-bilayer lipid structures induced by Ca2+ and cytochrome c in cardiolipin-containing liposomes. This drug also strongly inhibits the uptake of Ca2+ by cardiolipin into an organic phase. These results are discussed in relation to the cardiotoxic effect of adriamycin and the possible importance of non-bilayer lipid structures for the functioning of the mitochondrion. |
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Keywords: | Adriamycin Cardiolipin Cytochrome c Non-bilayer structure |
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