The polymorphic phase behaviour and miscibility properties of synthetic phosphatidylethanolamines |
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Authors: | CPS Tilcock PR Cullis |
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Institution: | Department of Biochemistry, University of British Columbia, Vancouver, B.C. V6T 1W5 Canada |
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Abstract: | (1) The polymorphic phase behaviour of aqueous dispersions of various synthetic phosphatidylethanolamines, both singly and in mixtures, has been investigated by 31P-NMR. (2) PE remains in the lamellar phase up to 90°C. PE exhibits a lamellar to hexagonal (HII) transition between 60°C and 63°C. For PE, the lamellar to hexagonal (HII) transition occurs between 7 and 12°C, whereas for PE, the hexagonal (HII) phase is the preferred structure above ?15°C. (3) Mixtures of PE and PE exhibit near-ideal miscibility behaviour. For mixtures of PE and PE there is evidence of fluid-solid immiscibility at temperatures below the gel-liquid crystalline transition temperature of the PE component. Mixtures of PE and PE exhibit complex phase behaviour involving limited fluid-solid immiscibility at low temperatures and formation of a phase allowing isotropic motional averaging at higher temperatures. (4) 31P-NMR provides a graphic method for investigating the miscibility properties of mixed PE systems. |
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Keywords: | Phosphatidylethanolamine Lamellar phase Phase behavior Miscibility PE phosphatidylethanolamine PC phosphatidylcholine PS phosphatidylserine PG phosphatidylglycerol DMSO dimethylsulphoxide |
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