Stabilization of bilayer structure for unsaturated phosphatidylethanolamines by detergents |
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Authors: | TD Madden PR Cullis |
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Institution: | Department of Biochemistry, University of British Columbia, Vancouver, B.C. V6T 1W5 Canada |
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Abstract: | The structural preferences of mixed lipid systems containing egg yolk or phosphatidylethanolamine and representative detergents (Triton X-100, deoxycholate, octylglucoside and lyso-phosphatidylcholine) have been examined. It is shown that all these detergents exhibit an ability to stabilize a bilayer organization for the phosphatidylethanolamine at detergent to phosphatidylethanolamine molar ratios of 0.05 to 0.5, depending on the detergent and/or phosphatidylethanolamine species. These results are interpreted in terms of molecular shape, where the ‘inverted cone’ shape detergents combine in a complementary fashion with ‘cone shaped’ phosphatidylethanolamine to result in net bilayer structure. |
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Keywords: | Phosphatidylethanolamine Octylglucoside Triton X-100 Bilayer structure |
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