Dopamine receptor genetic polymorphisms and body composition in undernourished pastoralists: An exploration of nutrition indices among nomadic and recently settled Ariaal men of northern Kenya |
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| Authors: | Dan TA Eisenberg Benjamin Campbell Peter B Gray Michael D Sorenson |
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| Institution: | (1) Department of Anthropology, Northwestern University, Evanston, IL, USA;(2) Department of Anthropology, University of Wisconsin Milwaukee, Milwaukee, WI, USA;(3) Department of Anthropology and Ethnic Studies, University of Nevada, Las Vegas, USA;(4) Department of Biology, Boston University, Boston, MA, USA |
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| Abstract: | Background Minor alleles of the human dopamine receptor polymorphisms, DRD2/TaqI A and DRD4/48 bp, are related to decreased functioning
and/or numbers of their respective receptors and have been shown to be correlated with body mass, height and food craving.
In addition, the 7R minor allele of the DRD4 gene is at a higher frequency in nomadic compared to sedentary populations. Here
we examine polymorphisms in the DRD2 and DRD4 genes with respect to body mass index (BMI) and height among men in two populations
of Ariaal pastoralists, one recently settled (n = 87) and the other still nomadic (n = 65). The Ariaal live in northern Kenya,
are chronically undernourished and are divided socially among age-sets. |
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