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Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells |
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| Authors: | Chang Dong Jo Jeong Mi Young Song Jiho Jin Chang Yun Suh Young-Ger Kim Hyun-Jung Min Kyung Hoon |
| Affiliation: | College of Pharmacy, Seoul National University, Seoul, Republic of Korea. |
| Abstract: | 1,3,4-Oxadiazole derivatives were found to enhance astrocyte differentiation in rat fetal neural stem cells (NSCs). Differentiation activity was assessed by immunocytochemistry and analysis of mRNA expression of astrocyte markers, GFAP and S100. Compounds 7 and 8 showed approximately a two-fold increase in astrocyte differentiation without engagement of neuronal differentiation and detectable cytotoxicity. |
| Keywords: | Neural stem cell Small molecule Astrocyte Differentiation 1,3,4-Oxadiazole |
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