In vitro study, in perfused rabbit heart, of interaction between two anti-arrhythmia agents: amiodarone and disopyramide |
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| Authors: | H Akhdim J P Kantelip B Stimmesse G Toubin P Magnin |
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| Affiliation: | Chaire de Pharmacologie, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besan?on. |
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| Abstract: | The influence of 15 day's amiodarone administration (30 mg/kg/day) on myocardial uptake kinetics and electrocardiographic changes of disopyramide was examined on the isolated perfused rabbit heart (n = 24) under electrical stimulation. Amiodarone significantly reduced myocardial uptake and potentialized the effect of disopyramide on intraventricular conduction. |
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