Inhibitors of the RNA and DNA Dependent Polymerase Activities of RNA Tumour Viruses |
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| Authors: | CORRADO GURGO RANJIT KUMAR RAY LISE THIRY MAURICE GREEN |
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| Institution: | 1.Institute for Molecular Virology,Saint Louis University School of Medicine,Saint Louis;2.Institut Pasteur Brabant,Brussels,Belgium |
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| Abstract: | RNA viruses of several animal leukaemias and sarcomas possess what seems so far to be a unique enzyme—an RNA dependent DNA polymerase1–6. Specific inhibitors of the viral enzyme will not only be useful in the analysis of its possible role in neoplasia, but might provide drugs for leukaemia and cancer therapy. |
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