真核生物DNA复制起始调控

复制起始调控是真核生物复制调控机制的重要环节，也是细胞生长调控的核心问题．对SV40病毒和酵母体系的研究为阐明真核生物的复制起始机制及其与细胞周期的关系提供了线索．目前，与DNA复制起始有关的多种蛋白质因子（如核蛋白P₁，DNA单链结合蛋白，DNA聚合酶α，增殖细胞核抗原等）的作用机理逐渐明朗，周期依赖的调控特点得到了证实文章着重介绍了DNA复制起始在细胞周期中的两个调控点及各种周期蛋白在该点的作用，文中还涉及复制起始异常与肿瘤发生的关系.

Regulation of DNA Replication Initiation in Eukaryotes

One of the most important mechanisms to regulate DNA replication in eukaryotic cells is to regulate the initiation of the replication. Investigations into SV40(simian 40)and Saccharomyces cerevisiae systems provide instructive suggestions to the mechanisms of replication initiation in eukaryotic systems and maneuvers with which the initiation are concerted with cell cycle. Many functions of protein factors involved in initiation of replication in eukaryotic cells are being clarified. And the cycle-dependent regulatory pattern is gaining experimental supports. Two regulation points in cell cycle for DNA replication initiation and the roles played by cyclins are mainly introduced. The relationship between carcinogenesis and the disturbance of replication-cycle is also discussed at appropriate point, which hints at the significance of initiation regulation.