| 人羧酯酶的研究进展 |
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| 引用本文： | 唐景荣,孙曼霁.人羧酯酶的研究进展[J].生物化学与生物物理进展,1996,23(2):113-117. |
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| 作者姓名： | 唐景荣 孙曼霁 |
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| 作者单位： | 军事医学科学院药物毒物研究所;军事医学科学院药物毒物研究所 |
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| 基金项目： | 解放军总后勤部攻关课题. |
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| 摘 要： | 羧酯酶是一类可与有机磷化合物结合且活性受抑制的B－酯酶，分布很广，能水解许多羧酯类、酰胺类、硫酯类物质，其天然底物尚未清楚，故其生理功能仍在研究中，可能与脂质代谢，药物或毒物的生物转化有关．对羧酯酶的一级结构及基因序列的研究表明，羧酯酶是由许多生化特性不同的同工酶组成．
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| 关 键 词： | 羧酯酸 生化特性 一级结构 活性位点 基因 |
| 收稿时间： | 4/7/1995 12:00:00 AM |
| 修稿时间： | 1995/6/10 0:00:00 |
Progress on Human Carboxylesterases |
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| Tang Jingrong and Sun Manji.Progress on Human Carboxylesterases[J].Progress In Biochemistry and Biophysics,1996,23(2):113-117. |
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| Authors: | Tang Jingrong and Sun Manji |
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| Institution: | Institute of Pharmacology and Toxicology, Academy Of Military Medical Sciences;Institute of Pharmacology and Toxicology, Academy Of Military Medical Sciences |
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| Abstract: | Carboxlesterases (EC3.1.1.1 ) can be inhibited by combining with organophosphorus compounds and classified into B-esterase.The enzymes are responsible for the hydrolysis of ester, thioester and amide bonds of many compounds although their natural substrate and physiological role are nuclear. Recently, it is found that purified carboxylesterase may play an important physiological role in biotransformation of drugs or xenobiotics and lipid metabolism.Human carboxylesterases consist of an important family of isoenzymes that have distinct biochemical characteristics with studies on the primary structure and gene sequence of many different isoenzymes. |
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| Keywords: | carboxylesterase biochemical characteristics primary structure active site gene |
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