| 降钙素和降钙素基因相关肽的选择性表达 |
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| 引用本文： | 杨绍华,陈俊杰.降钙素和降钙素基因相关肽的选择性表达[J].生物化学与生物物理进展,1996,23(1):34-38. |
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| 作者姓名： | 杨绍华 陈俊杰 |
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| 作者单位： | 华西医科大学重组DNA研究室;华西医科大学重组DNA研究室 |
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| 摘 要： | 降钙素和降钙素基因相关肽(CT/CGRP)由同一基因编码，该基因结构及其5＇端侧翼序列决定了它能够在甲状腺C细胞以及中枢和外周神经细胞生成不同的表达产物.这种选择表达调控决定多细胞生物的发育、性别分化和进化.如果表达失控将导致甲状腺髓样瘤(MTC)和骨质疏松症等疾病.文章对该基因的结构和选择性表达调控进行了综述.
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| 关 键 词： | 降钙素 降钙素基因相关肽 选择性表达 甲状腺髓样癌 |
| 收稿时间： | 1995/2/27 0:00:00 |
| 修稿时间： | 1995/4/14 0:00:00 |
Alternative Expression of Calcitonin and Calcitonin Gene Related Peptide |
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| Yang Shaohua and Chen Junjie.Alternative Expression of Calcitonin and Calcitonin Gene Related Peptide[J].Progress In Biochemistry and Biophysics,1996,23(1):34-38. |
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| Authors: | Yang Shaohua and Chen Junjie |
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| Institution: | Recombinant DNA Laboratory, West China University of Medical Sciences;Recombinant DNA Laboratory, West China University of Medical Sciences |
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| Abstract: | Calcitonin and calcitonin gene related peptide (CT/CGRP) are coded by a commensal gene, of which the structure and 5' flanking sequence make the differential expressive products from thyroid C cell or nerve cell. The regulation of alternative expression determines the growth, sexual differentiation and evolution in multicellular animals. The medullary thyroid carcinoma (MTC) or osteoporosis would arise supposing that the abnormal expressive regulation occurs. |
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| Keywords: | calcitonin calcitonin gene related peptide alternative expression medullary thyroid carcinoma |
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