E-cadherin在胃癌术后复发预测中的临床意义

目的:探讨E-cadherin在胃癌术后复发预测中的临床意义。方法:选择我院2006年1月至2010年7月收治的胃癌或者胃食管连接部癌行胃癌根治性切除术后259例患者为研究对象,将其分为术后复发组(115例)和术后未复发组(144例),采用免疫组织化学方法检测其E-cadherin的表达,并分析E-cadherin的异常表达与胃癌术后复发的相关性。结果:胃癌癌旁正常组织与胃癌组织间E-cadherin的表达有显著差异(P0.05);胃癌术后复发与未复发患者的胃癌组织E-cadherin的表达比较有显著差异(P0.05)。E-cadherin的异常表达与胃癌的浸润深度、淋巴结转移和TNM分期显著相关(P0.05)。单因素Logistic回归分析发现,E-cadherin的异常表达的与胃癌术后复发有显著的相关性(P=0.039,RR=1.711,95%Cl为1.486-1.970)。结论:E-cadherin的异常表达与胃癌根治性切除术后复发显著相关。

The Clinical Significance of E-cadherin in Predicting the Recurrence of Gastric Cancer after Curative Resection

Objective:To study the clinical significance of E-cadherin in predicting the recurrence of gastric cancer after curative resection.Methods:We studied 259 patients, including 115 patients inrecurrent group and 144 patients in non-recurrent group, who suffered gastric or gastroesophageal junction cancer after radical resection in our hospital fromJanuary 2006 to July 2010, the expression of E-cadherin in gastric cancer patients with recurrence and non-recurrence after radical resectionby were detected by immunohistochemistry and the correlation between abnormal expression of E-cadherin and gastric cancer recurrencewere analyzed.Results:There were significant differences of E-cadherin expression between normal gastric tissues and gastric cancer tissues (P<0.05); the E-cadherin expression of gastric cancer tissues of recurrent and non-recurrent patients with gastric cancer after surgery also had significant differences (P<0.05). Abnormal E-cadherin expression was significantly associated with the depth of invasion, lymph node metastasis and TNM staging of patients with gastric cancer (P<0.05); Univariate Logistic regression analysis showed that abnormal expression of E-cadherinwas correlated with the recurrence of gastric cancer after surgery (P=0.039, RR=1.711, 95% Cl=1.486-1.970).Conclusion:The abnormal expression of E-cadherin may be associated with the recurrence of gastric cancer after curative resection.