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Metabolism of isoflavones in human subjects |
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| Authors: | Heinonen Satu-Maarit Wähälä Kristiina Adlercreutz Herman |
| Institution: | 1.Folkh?lsan Research Center, and Department of Clinical Chemistry, Institute for Preventive Medicine, Nutrition and Cancer, P.O. Box 63 ;2.Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014, Finland ;3.Institute for Preventive Medicine, Nutrition and Cancer, Folkh?lsan Research Center, and Department of Clinical Chemistry, University of Helsinki, P.O. Box 63, FIN-00014, Finland ; |
| Abstract: | Isoflavones form a group of plant compounds that occur mainly in legumes, soy being the most important source in human diet. The high levels of isoflavones in the diet have been associated with a lowered risk for hormone-dependent diseases, including breast and prostate cancers, osteoporosis and cardiovascular disease. The metabolism of isoflavones in humans has been studied to a certain extent, but detailed studies are lacking. This paper reviews the current knowledge on metabolism of isoflavones and presents some preliminary results of a comprehensive soy feeding study, in which the phase I metabolites of soy isoflavones, daidzein, genistein and glycitein, were identified by GC-MS. This revised version was published online in June 2006 with corrections to the Cover Date. |
| Keywords: | biochanin A daidzein formononetin genistein glycitein isoflavone metabolism red clover soy |
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