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Aging of mesenchymal stem cell in vitro |
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| Authors: | Mohyeddin Mandana Bonab Kamran Alimoghaddam Fatemeh Talebian Syed Hamid Ghaffari Ardeshir Ghavamzadeh Behrouz Nikbin |
| Affiliation: | (1) Hematology-Oncology & BMT Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran;(2) Immunogenetics lab, Dept. of Immunology, Tehran University of Medical Sciences, College of Medicine, Tehran, Iran |
| Abstract: | BackgroundA hot new topic in medical treatment is the use of mesenchymal stem cells (MSC) in therapy. The low frequency of this subpopulation of stem cells in bone marrow (BM) necessitates their in vitro expansion prior to clinical use. We evaluated the effect of long term culture on the senescence of these cells. |
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