(1) Hematology-Oncology & BMT Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran;(2) Immunogenetics lab, Dept. of Immunology, Tehran University of Medical Sciences, College of Medicine, Tehran, Iran
Abstract:
Background
A hot new topic in medical treatment is the use of mesenchymal stem cells (MSC) in therapy. The low frequency of this subpopulation
of stem cells in bone marrow (BM) necessitates their in vitro expansion prior to clinical use. We evaluated the effect of
long term culture on the senescence of these cells.