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Sequence analysis and receptor specificity of the hemagglutinin of a recent influenza H2N2 virus isolated from chicken in North America |
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| Authors: | Laurel Glaser Dmitriy Zamarin Helen M Acland Erica Spackman Peter Palese Adolfo García-Sastre Deepanker Tewari |
| Institution: | (1) Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA;(2) Pennsylvania Department of Agriculture, Pennsylvania Veterinary Laboratory, Harrisburg, PA 17110, USA;(3) Agricultural Research Service, U.S. Department of Agriculture, Southeast Poultry Research Laboratory, Athens, GA 30605, USA;(4) Department of Microbiology and NorthEast Biodefense Center, Mount Sinai School of Medicine, New York, NY 10029, USA |
| Abstract: | Influenza viruses bind host cells following an interaction between the viral hemagglutinin (HA) protein and host cell sialylated glycoproteins and glycolipids. Differences in binding affinities of the HAs for different types of sialic acid linkages (α2-3 vs. α2-6) contribute to determining the host range of an influenza virus. The ability of an avian influenza virus HA to bind the human form of the receptor may be one requirement for an avian virus to propagate in the human population. In this paper, we describe the characterization of the HA from an H2N2 virus isolated from a Pennsylvania chicken farm in 2004. Sequence analysis revealed that this HA is a member of the Eurasian clade, and receptor binding studies show that it maintains its specificity for the avian influenza virus α2-3 linked sialic acid receptor. |
| Keywords: | Influenza virus Hemagglutinin Receptor Specificity Virus-host tropism Sialic acid |
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