[3H]Paroxetine Binding Is Altered in the Hippocampus but Not the Frontal Cortex or Caudate Nucleus from Subjects with Schizophrenia |
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| Authors: | † Brian Dean ‡Kenneth Opeskin Geoffrey Pavey †Lee Naylor Christine Hill §Nicholas Keks †David L Copolov |
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| Institution: | The Rebecca L. Cooper Laboratories, The Mental Health Research Institute of Victoria;; The NH and MRC Schizophrenia Research Unit, Royal Park Psychiatric Hospital, Parkville;; The Victorian Institute of Forensic Pathology, South Melbourne;and; Department of Psychiatry, The Alfred Hospital, Prahran, Victoria, Australia |
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| Abstract: | Abstract: 3H]Paroxetine binding to particulate membrane from tissue, obtained at autopsy, from the hippocampus, frontal cortex, and caudate nucleus from subjects who had or had not had schizophrenia was measured. The density of 3H]paroxetine binding to membranes from subjects who had or had not had schizophrenia did not differ. Similarly, the affinity of 3H]paroxetine binding in the frontal cortex and caudate nucleus was not different. By contrast, the affinity of 3H]paroxetine binding to hippocampal membrane from subjects who had schizophrenia was significantly lower than the affinity of binding for the nonschizophrenic subjects (0.40 ± 0.06 vs. 0.26 ± 0.02; p < 0.05). As 3H]paroxetine binds to the serotonin transporter, these data suggest that the serotonin transporter is altered in the hippocampus in subjects with schizophrenia. |
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| Keywords: | Schizophrenia Paroxetine Serotonin transporter Hippocampus Frontal cortex Caudate nucleus |
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