Effect of pyridoxine on the inhibition by dexamethasone of murine erythroleukemia cell differentiation |
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| Authors: | H.Beverley Osborne |
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| Affiliation: | Laboratoire de Biologie Moléculaire et Cellulaire, (E.R. 199 du C.N.R.S.), Département de Recherche Fondamentale, Centre d''Etudes Nucléaires de Grenoble, 85X, F-38041 Grenoble Cedex France |
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| Abstract: | Glucocorticoids are known to inhibit the induced differentiation of murine erythroleukemia cells. I show here that the binding of glucocorticoid receptors to the intact nuclei of these cells is reduced by exogenous extracellular pyridoxine (1–4 mM). This reduction of glucocorticoid-receptor binding did not abrogate the inhibition by dexamethasone of the induced differentiation. |
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| Keywords: | Glucocorticoid receptor Pyridoxine Differentiation inhibition (Murine erythroleukemia) |
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