Susceptibility of some clinical isolates of <Emphasis Type="Italic">Staphylococcus aureus</Emphasis> to fractions from the aerial parts of <Emphasis Type="Italic">Leuzea carthamoides</Emphasis> |
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Authors: | Dagmar Janovská Pavel Klou?ek Jan Urban Tomá? Vaněk Vojtěch Rada Ladislav Koko?ka |
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Institution: | Dagmar Janovská, Pavel Klou?ek, Jan Urban, Tomá? Vaněk, Vojtěch Rada and Ladislav Koko?ka |
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Abstract: | The antimicrobial activity of the dichloromethane extract from aerial parts of Leuzea carthamoides DC. was tested in vitro against 19 Staphylococcus aureus strains (ATCC 25923, CNCTC Mau 43/60, clinical isolates). The extract was fractionated by column chromatography on silica
gel into six fractions (petroleum ether, toluene, dichloromethane, ethyl acetate, methanol and water). The minimum inhibitory
concentrations (MICs) of the fractions ranged from 64 to 1024 μg/mL. An ethyl acetate fraction (EA 1) with the widest range
of activity inhibited all of the strains with MIC in the range 128–512 μg/mL. This fraction exhibited potent activity against
strains which showed associated resistance to oxacillin, ciprofloxacin and erythromycin. |
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Keywords: | Leuzea carthamoides aerial parts antimicrobial activity fractionation Staphylococcus aureus MRSA |
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