Curcumin and cyclopalladated complexes: a recipe for bifunctional biomaterials |
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| Authors: | Pucci Daniela Bloise Rossana Bellusci Anna Bernardini Sergio Ghedini Mauro Pirillo Sante Valentini Alessandra Crispini Alessandra |
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| Institution: | Centro di Eccellenza CEMIF.CAL-LASCAMM, CR-INSTM Unità della Calabria, Dipartimento di Chimica, Università della Calabria, Italy. d.pucci@unical.it |
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| Abstract: | The first examples of binuclear and mononuclear ortho-palladated complexes based on a functionalized 2-phenylquinoline ligand have been synthesized and fully characterized. Conjugating cyclopalladated fragments to curcumin family biologically active beta-diketones gives in one single molecule two different functionalities. The structural variations based on the curcuminoid structure have been tested for their in vitro cytotoxic activity. The activity of complexes comprised of a cyclopalladated fragment conjugated to functionalized bioactive ligands, represents the potential of organometallic systems in generating new bifunctional biomaterials. |
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| Keywords: | Cyclopalladated 2-phenylquinoline Curcumin X-ray crystal structure Cytotoxic activity |
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