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Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development |
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| Authors: | Gen-Bao Shao Jun-Chao Chen Liu-Ping Zhang Pan Huang Hong-Yan Lu Jie Jin Ai-Hua Gong Jian-Rong Sang |
| Institution: | 1. Department of Biology, School of Medical Science and Laboratory Medicine, Jiangsu University, 301 XueFu, Zhenjiang, 212013, China 2. Department of Pathology, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, 212013, China 3. Department of Pediatrics, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China 4. Department of Physiology, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, 212013, China |
| Abstract: | Extensive and dynamic chromatin remodeling occurs after fertilization, including DNA methylation and histone modifications. These changes underlie the transition from gametic to embryonic chromatin and are thought to facilitate early embryonic development. Histone H3 lysine 4 methylation (H3K4me) is an important epigenetic mechanism that associates with gene-specific activation and functions in development. However, dynamic regulation of H3K4me during early embryonic development remains unclear. Herein, the authors examined the dynamic changes of H3K4me and its key regulators (Ash1l, Ash2l, Kmt2a, Kmt2b, Kmt2c, Setd1a, Setd7, Kdm1a, Kdm1b, Kdm5a, Kdm5b, Kdm5c, and Kdm5d) in mouse oocytes and preimplantation embryos. An increase in levels of H3K4me2 and me3 was observed at the one- to two-cell stages (P?P?P? |
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