Inhibition ofPseudomonas aeruginosa alginate expression by subinhibitory concentrations of antibiotics |
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Authors: | V Majtán D Hybenová |
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Institution: | (1) Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovak Republic |
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Abstract: | The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of quinolones (ciprofloxacin, enoxacin, nalidixic
acid, norfloxacin, ofloxacin, pefloxacin), aminoglycosides (amikacin, gentamicin, netilmicin, streptomycin, tobramycin), β-lactams
(aztreonam, ceftazidime, imipenem, ticarcilin) and macrolides (erythromycin, roxitromycin) on the excretion of alginate by
aP. aeruginosa strain were studied. Both β-lactam and macrolide antibiotics were found ineffective at the concentrations tested, except
erythromycin and imipenem at 1/4 MIC. Aminoglycosides at a concentration of 1/4 MIC reduced most effectively the excretion
of alginate. Quinolones were also effective at this sub-MIC; 1/16 MIC was ineffective with all antibiotics or stimulated the
production of alginate. |
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Keywords: | |
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