Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans |
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| Institution: | 1. The Orthopedic Specialty Hospital, Murray, UT 84107, USA;2. ARUP Laboratories, Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA;3. Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA;4. USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA;5. Hyperbaric Medicine, Intermountain Medical Center, Murray, UT 84107, USA;6. Hyperbaric Medicine, LDS Hospital, Salt Lake City, UT 84143, USA;7. University of Utah, School of Medicine, Salt Lake City, UT 84132, USA;1. Faculty of Architectural, Civil Engineering and Environment, Ningbo University, Ningbo 315211, China;2. Institute of Complexity Science and Big Data Technology, Guangxi University, Nanning 530005, China;3. PMB Intelligence LLC, Sunnyvale, CA 94087, USA;1. Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil;2. Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil;1. L2TI, Université Paris 13, Sorbonne Paris Cité, France;2. XLIM, Dept. SIC, Université de Poitiers, France;1. Epilepsy Center, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany;2. BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Kohler-Allee 79, Freiburg 79110, Germany;3. Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg im Breisgau, Germany;4. Department of Neuropediatrics and Muscular Diseases, Universitätsklinikum Freiburg, Freiburg im Breisgau, Germany;1. University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany;2. Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany;3. University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany;4. Centre for Trophoblast Research, Medical School, Wayne State University, Detroit, MI, USA |
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| Abstract: | The purpose of this study was to identify the influence of vitamin D status (insufficient vs. sufficient) on circulating cytokines and skeletal muscle strength after muscular injury. To induce muscular injury, one randomly selected leg (SSC) performed exercise consisting of repetitive eccentric–concentric contractions. The other leg served as the control. An averaged serum 25(OH)D concentration from two blood samples collected before exercise and on separate occasions was used to establish vitamin D insufficiency (<30 ng/mL, n = 6) and sufficiency (>30 ng/mL, n = 7) in young, adult males. Serum cytokine concentrations, single-leg peak isometric force, and single-leg peak power output were measured before and during the days following the exercise protocol. The serum IL-10 and IL-13 responses to muscular injury were significantly (both p < 0.05) increased in the vitamin D sufficient group. The immediate and persistent (days) peak isometric force (p < 0.05) and peak power output (p < 0.05) deficits in the SSC leg after the exercise protocol were not ameliorated with vitamin D sufficiency. We conclude that vitamin D sufficiency increases the anti-inflammatory cytokine response to muscular injury. |
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| Keywords: | Vitamin D Cytokines Skeletal muscle strength |
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