Functional characterization and identification of mouse Rad51d splice variants |
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| Authors: | Aaron M Gruver Brian D Yard Campbell McInnes Changanamkandath Rajesh and Douglas L Pittman |
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| Institution: | (1) Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina Campus, Columbia, SC 29208, USA;(2) Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA |
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| Abstract: | Background The homologous recombination (HR) pathway is vital for maintaining genomic integrity through the restoration of double-stranded
breaks and interstrand crosslinks. The RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3) are essential for this process
in vertebrates, and the RAD51D paralog is unique in that it participates in both HR repair and telomere maintenance. RAD51D
is also known to directly interact with the RAD51C and XRCC2 proteins. Rad51d splice variants have been reported in mouse and human tissues, supportive of a role for alternative splicing in HR regulation.
The present study evaluated the interaction of the Rad51d splice isoform products with RAD51C and XRCC2 and their expression patterns. |
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