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Sensitization of human cells by inhibitors of DNA synthesis following the action of DNA-damaging agents |
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| Authors: | M.V. Filatov L.A. Noskin |
| Affiliation: | Leningrad Institute of Nuclear Physics, Gatchina, 188350, Leningrad District, U.S.S.R. |
| Abstract: | Inhibitors of DNA synthesis 1-β-arabinofuranosylcytosine (Ac) and hydroxyurea (Hu) taken together drastically sensitized human cells to the killing effect of DNA-damaging agents. For UV-irradiation this sensitization depended on the cells′ ability for excision repair. By using viscoelastometric methods of measurement of double-strand breaks (DSB) in the genome, it was established that the first DSB were generated after incubation of the damaged cells in the mixture of inhibitors at about the same dose when sensitization appeared. A scheme is proposed to described molecular events associated with the phenomenon studied. |
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