| 维拉帕米拮抗内皮素所引起的心肌损伤 |
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| 引用本文： | 唐朝枢,苏静怡.维拉帕米拮抗内皮素所引起的心肌损伤[J].生理学报,1990,42(4):374-378. |
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| 作者姓名： | 唐朝枢 苏静怡 |
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| 作者单位： | 北京医科大学病理生理教研室 心肺内分泌研究室
(唐朝枢，李兆萍，汤健)，北京医科大学病理生理教研室 心肺内分泌研究室(苏静怡) |
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| 摘 要： | 本实验用10~(-8)mol/L 内皮素灌流离体大鼠心脏,导致平均灌流压,心室内压急剧升高,±LV dP/dt_(max)值显著降低,心肌蛋白漏出和脂质过氧化物形成,心肌钙含量显著增加等严重心脏功能和组织损伤。钙通道阻滞剂维拉帕米,无论与内皮素同时灌流或在内皮素灌流以后应用,都能有效地拮抗内皮素的心脏损伤作用。
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| 关 键 词： | 心脏损伤 内皮素 钙拮抗剂 |
ANTAGONISM OF VERAPAMIL ON THE INJURIOUS ACTION OF ENDOTHELIN OF ISOLATED RAT HEART |
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| TANG CHAO-SHU,LI ZHAO-PING,TANG JIAN,SU JING-YI.ANTAGONISM OF VERAPAMIL ON THE INJURIOUS ACTION OF ENDOTHELIN OF ISOLATED RAT HEART[J].Acta Physiologica Sinica,1990,42(4):374-378. |
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| Authors: | TANG CHAO-SHU LI ZHAO-PING TANG JIAN SU JING-YI |
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| Institution: | Department of Pathophysiology, Beijing Medical University. |
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| Abstract: | Isolated rat hearts perfused with endothelin at a concentration of 10(-8) mol/L showed serious functional and cellular myocardial deterioration as manifested by a significant increase of mean perfusion and left ventricular pressure, decrease of +/- LV dp/dtmax, leakage of myocardial protein, formation of lipid peroxides, increase of myocardial calcium content, etc. Calcium channel blocker, verapamil, effectively antagonized the injurious action of endothelin on rat heart whether administered along with or after endothelin perfusion. |
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| Keywords: | endothelin calcium channel blocker heart |
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