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R5 Strains of Human Immunodeficiency Virus Type 1 from Rapid Progressors Lacking X4 Strains Do Not Possess X4-Type Pathogenicity in Human Thymus |
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| Authors: | Robert D Berkowitz Anglique B van &#x;t Wout Neeltje A Kootstra Mary E Moreno Valerie D Linquist-Stepps Christopher Bare Cheryl A Stoddart Hanneke Schuitemaker and Joseph M McCune |
| Institution: | Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, USA. |
| Abstract: | Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors. |
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