Design,synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones |
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| Authors: | Babasaheb P Bandgar Hemant V Chavan Laxman K Adsul Vishnu N Thakare Sadanand N Shringare Rafik Shaikh Rajesh N Gacche |
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| Institution: | 1. Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India;2. Department of Pharmacology, Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (Bk), Lonavala 410 401, India;3. Biochemistry Research Laboratory, School of Life Sciences, S.R.T.M. University, Nanded 431 606, Maharashtra, India |
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| Abstract: | A series of novel pyrazole integrated benzophenones (9a–j) have been designed, synthesized from 1-methyl-5-(2,4,6-trimethoxy-phenyl)-1H-pyrazole 6. The structures of the regioisomers 6 and 7 were determined by 2D 1H–1H COSY, 1H–13C HSQC and 1H–13C HMBC experiments. The newly synthesized compounds (9a–j) were evaluated for in vivo anti-inflammatory activity by carrageenan paw edema in rats and in vitro COX-1/COX-2 inhibition and antioxidant potential. Among the synthesized compounds, compounds 9b, 9d and 9f, were found to be active anti-inflammatory agents in addition to having potent antioxidant activity. |
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