Effect of ambient temperature and E. coli endotoxin upon the plasma iron level in wild house mice in winter season |
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Authors: | E Tęgowska E Wasilewska |
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Institution: | (1) Institute of Biology, Department of Animal Physiology, N. Copernicus University, ul. Gagarina 9, 87-100 Toru, Poland |
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Abstract: | Summary The effects of ambient temperatures of 10°C and 30°C and of E. coli endotoxin on brain temperature and plasma iron level were investigated in unrestrained wild house mice, Mus musculus. In control animals (i.p. saline-injected) exposed to cold environmenta the brain temperature decreased and plasma iron levels were lower than those observed under thermoneutral conditions (30°C). Animals injected i.p. with endotoxin (0.5 g·kg-1) and placed at 30°C showed a drop in plasma iron level during the fever episode. The results provide strong evidence for a relationship between brain temperature and plasma iron level in control mice under thermoneutral conditions, and show that during cold exposure or after injection of endotoxin, there is no linear correlation between brain temperature and plasma iron. Moreover, it was found that cold stress influences plasma iron level and that this influence is not mediated by changes in brain temperature.Abbreviations EP
endotoxin pyrogen
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T
A
ambient temperature
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T
Br
brain temperature
- T
Br
change in T
Br in relation to its initial value in feverish or control mice
- T
Br
difference between T
Br in feverish and control mice |
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Keywords: | Cold stress E coli endotoxin Brain temperature Plasma iron Wild mouse Mus musculus |
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