Homologous recombination promoted by Chi sites and RecBC enzyme of Escherichia coli |
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| Authors: | Gerald R. Smith Franklin W. Stahl |
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| Affiliation: | 1. Fred Hutchinson Cancer Research Center, 1124 Columbia St, Seattle, Washington 98104 USA;2. Institute of Molecular Biology, University of Oregon, Eugene, 97403, USA |
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| Abstract: | Chi sites are examples of special sites enhancing homologous recombination in their region of the chromosome. Chi, 5′ G-C-T-G-G-T-G-G3′, is a recognition site for the RecBC enzyme, which nicks DNA near Chi as it unwinds DNA. A molecular model of genetic recombination incorporating these features is reviewed. |
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