Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus |
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Authors: | Matsuda Kouhei Kojima Kenji Shimakura Sei-Ichi Miura Tohru Uchiyama Minoru Shioda Seiji Ando Hironori Takahashi Akiyoshi |
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Institution: | Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, Toyama, Toyama, Japan. kmatsuda@sci.u-toyama.ac.jp |
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Abstract: | Intracerebroventricular (ICV) administration of melanin-concentrating hormone (MCH) inhibits food intake in goldfish, unlike the orexigenic action in rodents, via the melanocortin system with suppression of neuropeptide Y (NPY) mRNA expression. We therefore investigated the neuronal relationship between MCH- and NPY-containing neurons in the goldfish brain, using a double-immunofluorescence method and confocal laser scanning microscopy. MCH- and NPY-like immunoreactivities were distributed throughout the brain. In particular, MCH-containing nerve fibers or endings lay in close apposition to NPY-containing neurons in a specific region of the hypothalamus, the nucleus posterioris periventricularis (NPPv). These observations suggest that MCH-containing neurons provide direct input to NPY-containing neurons in the NPPv of goldfish, and that MCH plays a crucial role in the regulation of feeding behavior as an anorexigenic neuropeptide, inhibiting the orexigenic activity of NPY. |
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