The role of glucagon in the regulation of blood glucose: Model studies |
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Authors: | Ruby Celeste Eugene Ackerman Laël C Gatewood Clayton Reynolds George D Molnar |
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Institution: | (1) Health Computer Sciences, University of Minnesota, 55455 Minneapolis, Minnesota, USA;(2) Department of Medicine, University of British Columbia, V6Z1Y6 Vancouver, British Columbia, Canada;(3) Department of Medicine, University of Alberta, T6G2EI Edmonton, Alberta, Canada |
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Abstract: | Mathematical models afford a procedure of unifying concepts and hypotheses by expressing quantitative relationships between
observables. The model presented indicates the roles of both insulin and glucagon as regulators of blood glucose, albeit in
different ranges of the blood glucose concentrations. Insulin secretion is induced during hyperglycemia, while glucagon secretion
results during hypoglycemia. These are demonstrated by simulations of a mathematical model conformed to data from the oral
glucose tolerance test and the insulin infusion test in normal control subjects and stable and unstable diabetic patients.
The model studies suggest the parameters could prove of value in quantifying the diabetic condition by indicating the degree
of instability.
Presented at the Society for Mathematical Biology Meeting, University of Pennsylvania, Philadelphia, August 19–21, 1976. |
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