Creatine synthesis and transport during rat embryogenesis: Spatiotemporal expression of AGAT,GAMT and CT1 |
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| Authors: | Olivier?Braissant mailto:Olivier.Braissant@chuv.ch" title=" Olivier.Braissant@chuv.ch" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Hugues?Henry,Anne-Marie?Villard,Oliver?Speer,Theo?Wallimann,Claude?Bachmann |
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| Affiliation: | 1.Clinical Chemistry Laboratory,University Hospital,Lausanne,Switzerland;2.Institute of Cell Biology,Swiss Federal Institute of Technology,Zürich,Switzerland;3.Institute of Molecular Biology,University of Zurich,Zürich,Switzerland |
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| Abstract: | ![]()
Background Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Recently, genetic defects of this pathway have been described, that lead to Cr deficiency, neurological symptoms in early infancy and severe neurodevelopmental delay. To investigate the involvement of Cr synthesis and uptake pathways during embryonic development, we determined the spatiotemporal expression of AGAT, GAMT and CT1 during the rat embryogenesis, at the mRNA and protein level. |
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