Additives and Enzyme Stability |
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| Authors: | C J Gray |
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| Institution: |
a Department of Chemistry, University of Birmingham, Birmingham, England |
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| Abstract: | The polypeptide chain of an enzyme is folded so that the necessary functional groups are brought together in the active site. Conformational changes may disrupt this arrangement and cause loss of enzymic activity. The effect of soluble additives on the unfolding process is discussed. Additives may be classified as substrates and similar ligands, small uncharged organic molecules, specific and non-specific ionic species, and polymers. |
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| Keywords: | Enzyme stability conformational changes inactivation stabilisation additives |
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