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MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells
Authors:Cheng-Der Wu  Yuan-Sung Kuo  Han-Chung Wu  Chin-Tarng Lin
Affiliation:(1) Institute of Pathology, College of Medicine, National Taiwan University, No. 7, Chung-Shan S. Rd, Taipei, 10002, Taiwan;(2) Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan No. 7, Chung-Shan S. Rd, Taipei, 10002, Taiwan;(3) Institute of Cellular and Organismic Biology, Academia Sinica, No. 128, Academia Rd, Section 2, Nankang, Taipei, 11529, Taiwan;(4) Department of Pathology, National Taiwan University Hospital, No. 7, Chung-Shan S. Rd, Taipei, 10002, Taiwan
Abstract:

Background  

MiR-1 (microRNA-1) has been used as a positive control in some microRNA experiments. We found that miR-1 transfection of nasopharyngeal carcinoma cells reveals a typical apoptotic process as shown by time-lapse microscopy so we investigated the mechanisms of miR-1 inducing apoptosis.
Keywords:nasopharyngeal carcinoma (NPC)   microRNA-1 (miR-1)   PTMA (prothymosin alpha   ProTalpha)   apoptosis
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